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#oncology

Articles tagged with #oncology

  1. 文獻摘要: Body composition radiomics combined with machine learning for early recurrence prediction in intrahepatic cholangiocarcinoma following curative surgery A Multi Center study

    Objectives 這項多中心研究開發並驗證了整合放射體學-臨床機器學習 (RCML) 模型，用於預測肝內膽管癌 (ICC) 根治性手術後的早期復發 (ER)。研究證明，相較於傳統的僅臨床或僅放射體學模型，身體組成放射體學 (body composition radiomics) 能顯著提升 ER 預測能力。本研究提出了一種新穎方法，利用常規術前 CT 影像量化全身代謝-免疫狀態，以實現個人化風險分層。此外，研究識別出特定的身體組成放射體學特徵，例如 SAT 衍生的 wavelet featu...

    Oct 24, 20251 min read4

  2. 文獻摘要: Artificial intelligence assisted assessment of metabolic response to tebentafusp in metastatic uveal melanoma a long axial field of view 18F FDG PET CT study

    Objectives 本研究首次評估人工智慧 (AI) 輔助定量和代謝反應評估，使用長軸視野 (LAFOV) [18F]FDG PET/CT 影像於接受 tebentafusp 治療的轉移性葡萄膜黑色素瘤 (mUM) 患者。主要貢獻包括：1) 證明自動化全身容積評估 mUM 腫瘤負荷（產生總代謝腫瘤體積 (TMTV) 和總病灶醣解 (TLG) 測量值）的可行性和可靠性。2) 發現基線和治療後 3 個月時，AI 衍生的 TMTV 和 TLG 值升高與較差的患者總體生存期 (OS) 顯著相關。3) ...

    Sep 6, 20252 min read6

  3. 文獻摘要: Cost utility analysis of 177Lu PSMA 617 radioligand therapy in second line and third line treatment for metastatic castration resistant prostate cancer mCRPC in Germany

    Objectives 評估了 177Lu-PSMA-617 radioligand therapy (PRLT) 用於德國 metastatic castration-resistant prostate cancer (mCRPC) 的成本效益，從法定健康保險的角度。 Model I (三線治療：PRLT + Standard-of-Care (SoC) 對比單獨 SoC) 顯示 PRLT + SoC 增加了成本 (€27,200) 並增加了 Quality-Adjusted Life Ye...

    May 11, 20252 min read10

  4. 文獻評讀: PSMA PET CT in biochemical recurrence of prostate cancer with PSA levels 0 2 ng mL a German multicenter analysis of conventional PSMA tracers including 68Ga Ga PSMA 11 68Ga Ga PSMA I amp T and 18F PSMA 1007

    Objectives 這項多中心研究評估了三種 Prostate-Specific Membrane Antigen (PSMA) Positron Emission Tomography/Computed Tomography (PET/CT) 追蹤劑 ([68Ga]Ga-PSMA-11, [68Ga]Ga-PSMA I&T, [18F]PSMA-1007) 在 321 位 Prostate Cancer (PC) Biochemical Recurrence (BCR) 且 Prostate...

    Apr 30, 20252 min read6

  5. Article Review: PSMA PET CT in biochemical recurrence of prostate cancer with PSA levels 0 2 ng mL a German multicenter analysis of conventional PSMA tracers including 68Ga Ga PSMA 11 68Ga Ga PSMA I amp T and 18F PSMA 1007

    Objectives This multicenter study evaluated the detection rates of three Prostate-Specific Membrane Antigen (PSMA) Positron Emission Tomography/Computed Tomography (PET/CT) tracers ([68Ga]Ga-PSMA-11, [68Ga]Ga-PSMA I&T, [18F]PSMA-1007) in 321 patients...

    Apr 30, 20253 min read3

  6. 文獻評讀: Efficacy of combined targeted radionuclide therapy and immune checkpoint Inhibition in animal tumour models a systematic review and meta analysis of the literature

    Objectives 本篇系統性回顧與統合分析整合了結合標靶放射性核素治療 (targeted radionuclide therapy, TRT) 與免疫檢查點抑制劑 (immune checkpoint inhibition, ICI) 的臨床前證據。 研究顯示，在動物腫瘤模型中，相較於未治療控制組、TRT 單一療法組及 ICI 單一療法組，合併 TRT/ICI 治療能顯著改善腫瘤生長控制並延長存活期。 研究結果提供了此合併策略具備治療潛力的臨床前概念驗證 (proof-of-concep...

    Apr 26, 20252 min read3